Drug Information

Drug General Information
Drug ID
D00QGB
Former ID
DIB014693
Drug Name
O-2442
Synonyms
DAT specific inhibitors, Organix; Dopamine transporter modulator, Organix; O-2442; O-2443; O-2642; O-506; O-509
Indication Cocaine addiction [ICD9: 304.2; ICD10:F14.2] Investigative [543975]
Company
Organix Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C1(=C(c2cc(c(cc2)Cl)Cl)C[C@@H]2CC[C@H]1S2)C(=O)OC
CAS Number
CAS 174643-75-5
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [543975]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 543975(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927).
Ref 543975(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927).

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