Target Information
Target General Infomation | |||||
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Target ID |
T95438
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Former ID |
TTDNR00670
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Target Name |
Excitatory amino acid transporter 2
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Gene Name |
SLC1A2
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Synonyms |
Glutamate/aspartatetransporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2; SLC1A2
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Target Type |
Research
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Function |
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
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BioChemical Class |
Dicarboxylate amino acid:cation symporter
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UniProt ID | |||||
Sequence |
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK |
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Inhibitor | DL-TBOA | Drug Info | [534556] | ||
SYM2081 | Drug Info | [534384] | |||
threo-3-methylglutamate | Drug Info | [534384] | |||
WAY-213613 | Drug Info | [527637] | |||
Modulator | [3H](2S,4R)-4-methylglutamate | Drug Info | [543967] | ||
[3H]D-aspartic acid | Drug Info | [543967] | |||
[3H]ETB-TBOA | Drug Info | [528479] | |||
[3H]L-aspartic acid | Drug Info | [543967] | |||
Pathways | |||||
PANTHER Pathway | Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group III pathway | |||||
WikiPathways | Amyotrophic lateral sclerosis (ALS) | ||||
References | |||||
Ref 527637 | Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. | ||||
Ref 528479 | Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302. Epub 2006 Oct 17. | ||||
Ref 534384 | Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51(5):809-15. |
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