Drug General Information
Drug ID
D04MSI
Former ID
DIB021052
Drug Name
threo-3-methylglutamate
Synonyms
(+/-)-threo-3-methylglutamic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467811]
Structure
Download
2D MOL
Formula
C6H11NO4
InChI
InChI=1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)
InChIKey
FHJNAFIJPFGZRI-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Excitatory amino acid transporter 2 Target Info Inhibitor [534384]
Excitatory amino acid transporter 4 Target Info Inhibitor [526025]
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
WikiPathways Amyotrophic lateral sclerosis (ALS)
References
Ref 467811(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4573).
Ref 526025Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7.
Ref 534384Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51(5):809-15.

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