Target General Infomation |
Target ID |
T69085
|
Former ID |
TTDC00119
|
Target Name |
Transcription factor AP-1
|
Gene Name |
JUN
|
Synonyms |
AP-1 transcription factor; AP1; Activator protein 1; Activator protein-1; C-jun proto-oncogene; P39; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; JUN
|
Target Type |
Discontinued
|
Function |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
|
Target Validation |
T69085
|
UniProt ID |
|
Sequence |
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
|
Structure |
1A02; 1FOS; 1JNM; 1JUN; 1S9K; 1T2K
|
Drugs and Mode of Action |
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) |
Pathways |
References |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.