Target General Infomation
Target ID
T67754
Former ID
TTDR00094
Target Name
Transketolase
Gene Name
TKT
Synonyms
TK; TKT
Target Type
Research
Function
Catalyzes the transfer ofa two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
BioChemical Class
Transferases of aldehyde or ketone residues
UniProt ID
EC Number
EC 2.2.1.1
Sequence
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
Inhibitor 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane Drug Info [551393]
Pathways
BioCyc Pathway Pentose phosphate pathway
Pentose phosphate pathway (non-oxidative branch)
KEGG Pathway Pentose phosphate pathway
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Biosynthesis of amino acids
PANTHER Pathway Pentose phosphate pathway
PathWhiz Pathway Pentose Phosphate Pathway
Warburg Effect
WikiPathways Metabolism of carbohydrates
Integration of energy metabolism
Pentose Phosphate Pathway
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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