Target Information

Target General Infomation
Target ID
T47081
Former ID
TTDS00323
Target Name
Peptidyl-prolyl cis-trans isomerase A
Gene Name
PPIA
Synonyms
CyPA; Cyclophilin A; Cyclosporin A-binding protein; PPIase; Rotamase; PPIA
Target Type
Successful
Disease Dietary shortage [ICD9: 260-269; ICD10: E40-E46]
Function
Ppiases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
BioChemical Class
Cis-trans-isomerases
UniProt ID
P62937
EC Number
EC 5.2.1.8
Sequence
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
Drugs and Mode of Action
Drug(s) L-Proline Drug Info Approved Dietary shortage [536004], [540275]
Inhibitor (3r)-1-Acetyl-3-Methylpiperidine Drug Info [551393]
1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea Drug Info [527996]
3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide Drug Info [527996]
4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide Drug Info [527996]
7-AMINO-4-METHYL-CHROMEN-2-ONE Drug Info [551374]
Ethyl Oxo(Piperidin-1-Yl)Acetate Drug Info [551374]
Binder L-Proline Drug Info [537008]
Pathways
Reactome Platelet degranulation
Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Basigin interactions
WikiPathways Signaling by the B Cell Receptor (BCR)
Host Interactions of HIV factors
HIV Life Cycle
JAK/STAT
Cell surface interactions at the vascular wall
References
Ref 536004Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803.
Ref 540275(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3314).
Ref 527996J Med Chem. 2006 Feb 9;49(3):900-10.Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
Ref 537008Mechanistic insight into the role of transition-state stabilization in cyclophilin A. J Am Chem Soc. 2009 Jan 14;131(1):147-52.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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