Drug Information

Drug General Information
Drug ID
D0DZ3X
Former ID
DAP000198
Drug Name
L-Proline
Synonyms
Carboxypyrrolidine; Pro; Prolina; Proline; Prolinum; Prolina [Spanish]; Prolinum [Latin]; CB 1707; L-Prolin; PRO (IUPACabbreviation); Proline (USP); Proline (VAN); Proline [USAN:INN]; H-Pro-OH; L-Proline (JAN); L-Proline-15N; L-alpha-Pyrrolidinecarboxylic acid; L-Proline, labeled with carbon-14; L-Pyrrolidine-2-carboxylic acid; L-(-)-Proline; L-(2,3-3H)Proline; (-)-(S)-Proline; (-)-2-Pyrrolidinecarboxylic acid; (-)-Proline; (-)-Proline (S)-2-Carboxypyrrolidine; (2S)-pyrrolidine-2-carboxylic acid; (L)-PROLINE; (S)-2-Carboxypyrrolidine; (S)-2-Pyrrolidinecarboxylic acid; (S)-Proline; (S)-Pyrrolidine-2-carboxylic acid; 2-pyrrolidinecarboxylic acid
Drug Type
Small molecular drug
Indication Dietary shortage [ICD9: 260-269; ICD10:E40-E46] Approved [536004], [540275]
Therapeutic Class
Dietary supplement
Structure
Download
2D MOL

3D MOL
Formula
C5H9NO2
InChI
InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKey
ONIBWKKTOPOVIA-BYPYZUCNSA-N
CAS Number
CAS 147-85-3
PubChem Compound ID
145742
PubChem Substance ID
3448, 608065, 838056, 841800, 3135874, 4253464, 6436528, 6436535, 6436537, 7847103, 7887166, 7890050, 8144250, 10248984, 10508477, 14710669, 15146482, 15194368, 17435868, 24882005, 24887885, 24887886, 24898097, 24898677, 24898986, 24901637, 24902491, 41102174, 46223069, 46504839, 46506858, 49856395, 50108816, 57288676, 57346151, 57652885, 57652886, 57654568, 77943168, 81044534, 81067296, 85164895, 85182322, 85201946, 87574669, 92298421, 92710581, 96021916, 96100167, 99206182
ChEBI ID
ChEBI:17203
Target and Pathway
Target(s) Peptidyl-prolyl cis-trans isomerase B Target Info Binder [536004]
Peptidyl-prolyl cis-trans isomerase A Target Info Binder [537008]
Pathway Interaction Database Syndecan-1-mediated signaling events
PathWhiz Pathway Retinol Metabolism
Reactome Collagen biosynthesis and modifying enzymesR-HSA-114608:Platelet degranulation
Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Basigin interactions
WikiPathways Collagen biosynthesis and modifying enzymes
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2746:Signaling by the B Cell Receptor (BCR)
Host Interactions of HIV factors
HIV Life Cycle
JAK/STAT
Cell surface interactions at the vascular wall
References
Ref 536004Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803.
Ref 540275(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3314).
Ref 536004Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803.
Ref 537008Mechanistic insight into the role of transition-state stabilization in cyclophilin A. J Am Chem Soc. 2009 Jan 14;131(1):147-52.

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