Target Information
Target General Infomation | |||||
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Target ID |
T15882
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Former ID |
TTDI02312
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Target Name |
Leukocyte proteinase-3
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Gene Name |
PRTN3
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Synonyms |
AGP7; CANCA antigen; Leukocyte proteinase 3; Myeloblastin; NP4; Neutrophil proteinase 4; P29; PR3; Wegener autoantigen; PRTN3
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Target Type |
Clinical Trial
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Disease | Myeloid leukemia [ICD9: 208.9; ICD10: C92] | ||||
Myocardial infarction [ICD9: 410; ICD10: I21, I22] | |||||
Function |
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
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BioChemical Class |
Peptidase
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UniProt ID | |||||
EC Number |
EC 3.4.21.76
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Sequence |
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL
IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVL LIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTF FCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYV DWIRSTLRRVEAKGRP |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
Pathway Interaction Database | C-MYB transcription factor network | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
References |
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