Drug Information

Drug General Information
Drug ID
D0O8AY
Former ID
DIB016338
Drug Name
Combined PR1/WT1 vaccine
Synonyms
Combined PR1/WT1 vaccine (leukemia); Combined PR1/WT1 vaccine (leukemia), NIH; Proteinase 1/Wilms tumor 1 vaccine (leukemia), NIH
Drug Type
Vaccine
Indication Myeloid leukemia [ICD9: 208.9; ICD10:C92] Phase 2 [533145]
Company
National Institutes of Health
Target and Pathway
Target(s) Leukocyte proteinase-3 Target Info [529050]
Wilms' tumor protein Target Info [529050]
KEGG Pathway Transcriptional misregulation in cancer
NetPath Pathway FSH Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database C-MYB transcription factor networkp73pathway:p73 transcription factor network
Regulation of Telomerase
Reactome Common Pathway of Fibrin Clot Formation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
Integrated Pancreatic Cancer Pathway
References
Ref 533145Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies. Front Immunol. 2015 Feb 4;6:36.
Ref 529050Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42. Epub 2007 Sep 17.

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