Target Information
Target General Infomation | |||||
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Target ID |
T15514
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Former ID |
TTDR00269
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Target Name |
Hepatocyte nuclear factor 4-alpha
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Gene Name |
HNF4A
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Synonyms |
HNF-4-alpha; Transcription factor 14; Transcription factor HNF-4; HNF4A
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Target Type |
Research
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Function |
Transcriptionally controlled transcription factor. Binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. May be essential for development of the liver, kidney and intestine.
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BioChemical Class |
Nuclear hormone receptor
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UniProt ID | |||||
Sequence |
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI |
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Pathways | |||||
KEGG Pathway | AMPK signaling pathway | ||||
Maturity onset diabetes of the young | |||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
FOXA2 and FOXA3 transcription factor networks | |||||
HIF-1-alpha transcription factor network | |||||
Reactome | Nuclear Receptor transcription pathway | ||||
WikiPathways | Mesodermal Commitment Pathway | ||||
Integrated Pancreatic Cancer Pathway | |||||
Nuclear Receptors | |||||
AMPK Signaling | |||||
References |
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