Drug General Information
Drug ID
D02RRY
Former ID
DIB018969
Drug Name
BI6015
Synonyms
BI 6015; BI-6015
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541800]
Structure
Download
2D MOL
Formula
C15H13N3O4S
InChI
InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3
InChIKey
ILVCPQPMRPHZSG-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Hepatocyte nuclear factor 4-alpha Target Info Antagonist [531980]
KEGG Pathway AMPK signaling pathway
Maturity onset diabetes of the young
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
Reactome Nuclear Receptor transcription pathway
WikiPathways Mesodermal Commitment Pathway
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
AMPK Signaling
References
Ref 541800(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6695).
Ref 531980HNF4alpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18.

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