| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T72295 | ||||
| Target Name | mRNA of Protein kinase C-theta | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 8-Octyl-benzolactam-V9 | Drug Info | Ki = 290 nM | [528158] | |
| 4-(1H-indol-6-ylamino)-5-styrylnicotinonitrile | Drug Info | IC50 = 1400 nM | [530390] | ||
| 4-(1H-indol-5-yloxy)-5-styrylnicotinonitrile | Drug Info | IC50 = 690 nM | [530390] | ||
| 4-(1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info | IC50 = 24 nM | [530390] | ||
| 4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile | Drug Info | IC50 = 13 nM | [530390] | ||
| PROSTRATIN | Drug Info | Ki = 190 nM | [527606] | ||
| References | |||||
| Ref 528158 | J Med Chem. 2006 May 4;49(9):2681-8.Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. | ||||
| Ref 530390 | Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. | ||||
| Ref 530390 | Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. | ||||
| Ref 530390 | Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. | ||||
| Ref 530390 | Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. | ||||
| Ref 527606 | J Med Chem. 1992 May 29;35(11):1978-86.A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. | ||||
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