Target Validation Information
Target ID T21507
Target Name Fatty acid-bindingprotein, epidermal
Target Type
Research
Drug Potency against Target BMS-480404 Drug Info Ki = 33 nM [528353]
2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid Drug Info Ki = 3 nM [528353]
5-Carbazol-9-yl-pentanoic acid Drug Info IC50 = 3000 nM [527208]
2-(Carbazole-9-sulfonyl)-benzoic acid Drug Info IC50 = 17000 nM [527208]
4-Carbazol-9-yl-butyric acid Drug Info IC50 = 6700 nM [527208]
Hexadecanoic acid Drug Info IC50 = 1200 nM [527208]
References
Ref 528353J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.
Ref 528353J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.
Ref 527208Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.
Ref 527208Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.
Ref 527208Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.
Ref 527208Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.

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