Target Validation Information
Target ID T06037
Target Name mRNA of human Jun-N-terminal kinase-2 (JNK2)
Target Type
Research
Drug Potency against Target N-(4-amino-6-butoxy-5-cyanopyridin-2-yl)acetamide Drug Info IC50 = 4663 nM [528237]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide Drug Info Ki = 1900 nM [528237]
N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide Drug Info Ki = 440 nM [528237]
AS-601245 Drug Info IC50 = 5000 nM [529039]
References
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.

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