Drug Information

Drug General Information
Drug ID
D04QCF
Former ID
DNC008391
Drug Name
AS-601245
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541262]
Structure
Download
2D MOL

3D MOL
Formula
C20H16N6S
InChI
InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+
InChIKey
AVLYNJZZQYEFEA-XDJHFCHBSA-N
PubChem Compound ID
11422035
PubChem Substance ID
26758996, 42501134, 46535496, 53790218, 57376623, 77934538, 99302750, 103459815, 134345596, 135351279, 139264934, 141074720, 163687852, 175607490, 178102619, 180372398, 204370501, 237337770
Target and Pathway
Target(s) Mitogen-activated protein kinase 10 Target Info Inhibitor [529213]
mRNA of human Jun-N-terminal kinase-2 (JNK2) Target Info Inhibitor [529039]
Mitogen-activated protein kinase 8 Target Info Inhibitor [529039]
Glycogen synthase kinase-3 beta Target Info Inhibitor [529039]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
T cell receptor signaling pathway
HTLV-I infection
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
PI3K-Akt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
B cell receptor signaling pathway
Melanogenesis
Thyroid hormone signaling pathway
Alzheimer's disease
Measles
Endometrial cancer
Prostate cancer
Basal cell carcinoma
NetPath Pathway IL5 Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
B cell activation
EGF receptor signaling pathway
FAS signaling pathway
FGF signaling pathway
Integrin signalling pathway
Interferon-gamma signaling pathway
Parkinson disease
TGF-beta signaling pathway
Ras Pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Huntington disease
Oxidative stress response
T cell activation
Toll receptor signaling pathway
Angiogenesis
PDGF signaling pathway
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PI3 kinase pathway
Wnt signaling pathway
CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
CD40/CD40L signaling
FAS (CD95) signaling pathway
Glucocorticoid receptor regulatory network
FoxO family signaling
p75(NTR)-mediated signaling
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocytewnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
Rapid glucocorticoid signaling
ErbB1 downstream signaling
ATF-2 transcription factor network
Nephrin/Neph1 signaling in the kidney podocyte
p53 pathway
Downstream signaling in na&#xef
RAC1 signaling pathway
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4fcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
RhoA signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
Reelin signaling pathway
TRAIL signaling pathway
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
IL1-mediated signaling events
Ceramide signaling pathway
Regulation of Androgen receptor activity
JNK signaling in the CD4+ TCR pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Retinoic acid receptors-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
N-cadherin signaling events
S1P2 pathway
IL12 signaling mediated by STAT4lysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
LKB1 signaling events
Canonical Wnt signaling pathway
C-MYC pathway
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
Trk receptor signaling mediated by PI3K and PLC-gamma
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factorsR-HSA-2559580:Oxidative Stress Induced Senescence
Activation of the AP-1 family of transcription factorsR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
DSCAM interactions
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-195253:Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
G13 Signaling Pathway
Insulin Signaling
Wnt Signaling Pathway
MAPK Cascade
Oxidative Stress
Wnt Signaling Pathway and Pluripotency
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Apoptosis
BDNF signaling pathway
Integrin-mediated Cell Adhesion
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
TCR Signaling Pathway
TGF Beta Signaling Pathway
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
Wnt Signaling Pathway Netpath
JAK/STAT
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
ErbB Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Transcriptional activation by NRF2
NLR Proteins
IL-3 Signaling Pathway
Cardiac Hypertrophic Response
EBV LMP1 signaling
PDGF Pathway
Nanoparticle triggered regulated necrosis
Prostate Cancer
Leptin signaling pathway
Signalling by NGF
Intrinsic Pathway for Apoptosis
DSCAM interactions
Apoptosis Modulation and Signaling
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteoclast SignalingWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
IL-6 signaling pathway
Copper homeostasis
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
Regulation of Microtubule Cytoskeleton
Semaphorin interactions
Cell Cycle
Androgen receptor signaling pathway
IL-5 Signaling Pathway
References
Ref 541262(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5997).
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.
Ref 529213Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.