Target Validation Information
Target ID T74952
Target Name CAMP-dependent protein kinase type II-beta regulatory chain
Target Type
Discontinued
Drug Potency against Target AdcAhxArg4NH(CH2)6NH2 Drug Info IC50 = 680 nM [526704]
Ro-4396686 Drug Info IC50 = 9010 nM [528018]
BALANOL Drug Info Ki = 4.7 nM [527710]
AdcAhxArg4Lys-PEGOMe Drug Info IC50 = 460 nM [526704]
AdcAhxArg4Lys(biotin)-PEG-OMe Drug Info IC50 = 1200 nM [526704]
AdoC(Aun)Arg6 Drug Info IC50 = 330 nM [525511]
AdoC(betaAsp)2AlaArg6 Drug Info IC50 = 11100 nM [525511]
AdoCGlyArg6 Drug Info IC50 = 4000 nM [525511]
AdoC(Aoc)Arg6 Drug Info IC50 = 240 nM [525511]
AdcAhxArg6 Drug Info IC50 = 700 nM [526704]
AdoC(Dpr)2AlaArg6 Drug Info IC50 = 2600 nM [525511]
AdoC(GABA)Arg6 Drug Info IC50 = 1300 nM [525511]
AdoC(beta-Ala)2AlaArg6 Drug Info IC50 = 4300 nM [525511]
AdoC(Ahx)Arg6 Drug Info IC50 = 120 nM [525511]
AdoC(beta-Ala)Arg6 Drug Info IC50 = 1800 nM [525511]
References
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 528018Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. Epub 2006 Feb 3.Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
Ref 527710J Med Chem. 2005 Sep 8;48(18):5613-38.Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.

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