| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T15851 | ||||
| Target Name | Orotidine 5'-monophosphate decarboxylase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 5-Fluoro-6-ethyluridine-5'-O-monophosphate | Drug Info | Ki = 350 nM | [529995] | |
| 5-fluoro-6-iodo-UMP | Drug Info | Ki = 1100 nM | [529995] | ||
| 5-fluoro-6-azido-UMP | Drug Info | Ki = 18200 nM | [529995] | ||
| 5-fluoro-6-amino-UMP | Drug Info | Ki = 16600 nM | [529995] | ||
| References | |||||
| Ref 529995 | J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. | ||||
| Ref 529995 | J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. | ||||
| Ref 529995 | J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. | ||||
| Ref 529995 | J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.