Drug Information

Drug General Information
Drug ID
D0DW2F
Former ID
DNC009673
Drug Name
5-fluoro-6-iodo-UMP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529995]
Structure
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2D MOL

3D MOL
Formula
C9H11FIN2O9P
Canonical SMILES
C(C1C(C(C(O1)N2C(=C(C(=O)NC2=O)F)I)O)O)OP(=O)(O)O
InChI
1S/C9H11FIN2O9P/c10-3-6(11)13(9(17)12-7(3)16)8-5(15)4(14)2(22-8)1-21-23(18,19)20/h2,4-5,8,14-15H,1H2,(H,12,16,17)(H2,18,19,20)/t2-,4-,5-,8-/m1/s1
InChIKey
NJSVPTGGTXIMLP-UMMCILCDSA-N
PubChem Compound ID
16124514
Target and Pathway
Target(s) Orotidine 5'-monophosphate decarboxylase Target Info Inhibitor [529995]
BioCyc Pathway Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine ribonucleotides de novo biosynthesis
UMP biosynthesis
KEGG Pathway Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.

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