Target Validation Information
Target ID T59190
Target Name Protein kinase C, zeta type
Target Type
Discontinued
Drug Potency against Target Indolocarbazole analogue Drug Info IC50 = 3 nM [526234]
RO-320432 Drug Info IC50 = 21 nM
LY-317644 Drug Info IC50 = 6400 nM
LY-326449 Drug Info IC50 = 630 nM [534154]
[2,2':5',2'']Terthiophen-4-yl-methanol Drug Info IC50 = 3000 nM [525575]
RO-316233 Drug Info IC50 = 550 nM [528701]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde Drug Info IC50 = 700 nM [525575]
[2,2':5',2'']Terthiophene-4-carbaldehyde Drug Info IC50 = 5000 nM [525575]
Ro-32-0557 Drug Info IC50 = 6.8 nM
References
Ref 526234Bioorg Med Chem Lett. 2002 Jan 21;12(2):147-50.Mixed lineage kinase activity of indolocarbazole analogues.
Ref 534154J Med Chem. 1996 Jul 5;39(14):2664-71.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Ref 525575Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.
Ref 528701J Med Chem. 1992 Jan;35(1):177-84.Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Ref 525575Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.
Ref 525575Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.

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