Target Validation Information
Target ID T31479
Target Name Phospholipase A2
Target Type
Successful
Drug Potency against Target Petrosaspongiolide P Drug Info IC50 = 3800 nM [534632]
BOLINAQUINONE Drug Info IC50 = 100 nM [526069]
4'-hydroxy-6,3',5'-triprenylisoflavonone Drug Info IC50 = 10000 nM
Mepacrine Drug Info IC50 = 17 uM
3,9-dihydroxy-2,10-diprenylpterocap-6a-ene Drug Info IC50 = 3000 nM
ABYSSINONE V Drug Info IC50 = 6000 nM
URSOLIC ACID Drug Info IC50 = 2300 nM [527616]
HELENAQUINONE Drug Info IC50 = 3700 nM [531037]
CACOSPONGIONOLIDE Drug Info IC50 = 2300 nM [534672]
MANOALIDE Drug Info IC50 = 400 nM [528597]
HYRTIOSULAWESINE Drug Info IC50 = 14000 nM [528597]
References
Ref 534632J Nat Prod. 1998 May;61(5):571-5.Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra.
Ref 526069J Nat Prod. 2001 May;64(5):612-5.New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.
Ref 527616Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes.
Ref 531037Bioorg Med Chem. 2010 Aug 15;18(16):6006-11. Epub 2010 Jun 25.New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.
Ref 534672J Nat Prod. 1998 Jul;61(7):931-5.A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
Ref 528597J Nat Prod. 2006 Dec;69(12):1676-9.Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus.
Ref 528597J Nat Prod. 2006 Dec;69(12):1676-9.Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus.

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