Drug General Information
Drug ID
D02IVU
Former ID
DNC008859
Drug Name
CACOSPONGIONOLIDE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534672]
Structure
Download
2D MOL

3D MOL

Formula
C25H36O4
Canonical SMILES
CC1CCC23CC2(CCCC3C1(C)CCC4=CCC(OC4)C5=CC(=O)OC5O)C
InChI
1S/C25H36O4/c1-16-8-12-25-15-23(25,2)10-4-5-20(25)24(16,3)11-9-17-6-7-19(28-14-17)18-13-21(26)29-22(18)27/h6,13,16,19-20,22,27H,4-5,7-12,14-15H2,1-3H3/t16-,19+,20+,22+,23-,24-,25-/m0/s1
InChIKey
FPUWYDSKOKLTDH-FRMRWZTPSA-N
PubChem Compound ID
Target and Pathway
Target(s) Phospholipase A2, membrane associated Target Info Inhibitor [534672]
Phospholipase A2 Target Info Inhibitor [534672]
BioCyc Pathway PhospholipasesLIPASYN-PWY:Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorptionhsa00564:Glycerophospholipid metabolism
Fat digestion and absorption
Pathway Interaction Database Glypican 1 networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PIR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PI
WikiPathways Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Spinal Cord Injury
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophyWP2740:Glycerophospholipid biosynthesis
References
Ref 534672J Nat Prod. 1998 Jul;61(7):931-5.A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
Ref 534672J Nat Prod. 1998 Jul;61(7):931-5.A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.

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