Drug Information

Drug General Information
Drug ID
D04XWX
Former ID
DIB003581
Drug Name
PS-178990
Synonyms
SARMs (muscle wasting disease), BMS; SARMs (muscle wasting disease), Ligand; SARMs (muscle wasting disease), Pharmacopeia; Selective androgen receptor modulators (muscle wasting disease), BMS; Selective androgen receptor modulators (muscle wasting disease), Ligand; Selective androgen receptor modulators (muscle wasting disease), Pharmacopeia
Indication Muscle atrophy [ICD10:M62.5] Phase 1 [548632]
Company
Bristol-Myers Squibb Co
Target and Pathway
Target(s) Androgen receptor Target Info Binder [544063]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 548632Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027228)
Ref 544063Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal. 2008; 6: e010.

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