Drug Information

Drug General Information
Drug ID
D0RV6F
Former ID
DIB008904
Drug Name
MK-0773
Synonyms
C-8500; MK-773
Drug Type
Small molecular drug
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Phase 2 [522114]
Company
Merck & Co Inc
Structure
Download
2D MOL

3D MOL
Formula
C27H34FN5O2
Canonical SMILES
C1(=C[C@]2([C@H](N(C1=O)C)CC[C@@H]1[C@@H]2CC[C@]2([C@H]<br />1CC[C@@H]2C(=O)NCc1nc2c([nH]1)nccc2)C)C)F
PubChem Compound ID
11950726
Target and Pathway
Target(s) Androgen receptor Target Info Modulator [530821]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 522114ClinicalTrials.gov (NCT00529659) A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005). U.S. National Institutes of Health.
Ref 530821Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. J Biol Chem. 2010 May 28;285(22):17054-64.

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