Drug Information

Drug General Information
Drug ID
D09BZY
Former ID
DIB013761
Drug Name
Nibentan
Synonyms
HE-11; Rac-N-[5-(Diethylamino)-1-phenylpentyl]-4-nitrobenzamide hydrochloride
Drug Type
Small molecular drug
Indication Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] Phase 1 [534342]
Structure
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2D MOL

3D MOL
Formula
C22H30ClN3O3
Canonical SMILES
CCN(CC)CCCCC(C1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)[N+](=O)[O-<br />].Cl
InChI
1S/C22H29N3O3.ClH/c1-3-24(4-2)17-9-8-12-21(18-10-6-5-7-11-18)23-22(26)19-13-15-20(16-14-19)25(27)28;/h5-7,10-11,13-16,21H,3-4,8-9,12,17H2,1-2H3,(H,23,26);1H
InChIKey
CHCBAYRWJULIDW-UHFFFAOYSA-N
CAS Number
CAS 157832-55-8
PubChem Compound ID
177905
PubChem Substance ID
3372012, 10258797, 12014992, 14831604, 33501249, 53407494, 57395578, 93373994, 95663584, 104426765, 109658295, 123846888, 125622318, 126603305, 131487409, 135155579, 135252380, 143449415, 162058258, 162794983, 164772949, 169029591, 185980630, 234962276, 252484804
Target and Pathway
Target(s) Potassium channel Target Info Blocker [527507], [531635]
References
Ref 534342Electrophysiologic effects of nibentan (HE-11) on canine cardiac tissue. J Pharmacol Exp Ther. 1997 Mar;280(3):1137-46.
Ref 527507Nibentan -- a drug for pharmacological cardioversion of persistent atrial fibrillation. Kardiologiia. 2005;45(3):19-23.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.

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