Target Information

Target General Infomation
Target ID
T67952
Former ID
TTDR00174
Target Name
Potassium channel
Target Type
Successful
Disease Alopecia [ICD9: 704.09; ICD10: L65.9]
Arteriosclerosis [ICD9: 440; ICD10: I70]
Atrial fibrillation; Atrial flutter [ICD9: 427.31, 487, 488; ICD10: I48, J10, J11]
Atrial fibrillation [ICD9: 272, 427.31; ICD10: E78, I48]
Arrhythmia [ICD9: 427; ICD10: I47-I49]
Angina pectoris [ICD9: 413; ICD10: I20]
Asthma [ICD10: J45]
Cardiac arrhythmias [ICD9: 427; ICD10: I47-I49]
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63]
Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10: J40-J44, J47]
Diabetes [ICD9: 253.5, 588.1; ICD10: E23.2, N25.1]
High blood pressure [ICD9: 401; ICD10: I10-I16]
Hypertension [ICD9: 401; ICD10: I10-I16]
Heart arrhythmia [ICD10: I47-I49]
Multiple scierosis [ICD9: 340; ICD10: G35]
Maintenance of normal sinus rhythm [ICD9: 427; ICD10: I46-I49]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Nerve injury [ICD10: T14.4]
Ocular hypertension [ICD9: 365.04; ICD10: H40.0]
Overactive bladder disorder [ICD9: 188, 596.51; ICD10: C67, N32.81]
Obstructive sleep apnea [ICD9: 327.23, 780.57; ICD10: G47.3]
Rhinitis [ICD9: 472.0, 477; ICD10: J00, J30, J31.0]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Tachyarrhythmias [ICD9: 427, 785.0; ICD10: I47-I49, R00.0]
Urinary incontinence [ICD9: 788.3; ICD10: N39.3, N39.4, R32]
Unspecified [ICD code not available]
Drugs and Mode of Action
Drug(s) Amiodarone Drug Info Approved Tachyarrhythmias [536095], [539657]
Dalfampridine Drug Info Approved Multiple scierosis [531351]
Diazoxide Drug Info Approved Hypertension [538482], [539538]
Dofetilide Drug Info Approved Maintenance of normal sinus rhythm [536095], [539681]
Ibutilide Drug Info Approved Atrial fibrillation [536095], [542214]
Minoxidil Drug Info Approved Hypertension [467589], [538235]
Nateglinide Drug Info Approved Diabetes [536361], [541914]
Pinacidil Drug Info Approved High blood pressure [538525], [539542]
Andolast Drug Info Phase 3 Rhinitis [545161]
Azimilide Drug Info Phase 3 Atrial fibrillation [536095], [539666]
AZD-7009 Drug Info Phase 2 Atrial fibrillation [521760]
Bimakalim Drug Info Phase 2 Angina pectoris [527063]
HBI-3000 Drug Info Phase 2 Heart arrhythmia [523241]
MSH-1001 Drug Info Phase 2 Ocular hypertension [548251]
RP-49356 Drug Info Phase 2 Hypertension [544588]
YM-934 Drug Info Phase 2 Angina pectoris [544960]
AVE0118 Drug Info Phase 1 Obstructive sleep apnea [547751]
CLP-1004 Drug Info Phase 1 Hypertension [549413]
Iptakalim hydrochloride Drug Info Phase 1 Hypertension [531817]
Nibentan Drug Info Phase 1 Cardiac arrhythmias [534342]
NS-8 Drug Info Phase 1 Urinary incontinence [551445]
UK-66914 Drug Info Phase 1 Cardiac arrhythmias [544558]
Levcromakalim Drug Info Discontinued in Preregistration Chronic obstructive pulmonary disease [544517]
Acecainide Drug Info Discontinued in Phase 3 Solid tumours [544619]
Alinidine Drug Info Discontinued in Phase 3 Angina pectoris [544609]
Almokalant Drug Info Discontinued in Phase 3 Cardiac arrhythmias [544820]
BMS-204352 Drug Info Discontinued in Phase 3 Nerve injury [539459], [546835]
Ambasilide Drug Info Discontinued in Phase 2 Cardiac arrhythmias [544977]
BMS-180448 Drug Info Discontinued in Phase 2 Angina pectoris [545720]
BRL-32872A Drug Info Discontinued in Phase 2 Cardiac arrhythmias [544642]
BRL-55834 Drug Info Discontinued in Phase 2 Chronic obstructive pulmonary disease [544932]
E-4031 Drug Info Discontinued in Phase 2 Cardiac arrhythmias [539682], [544654]
JTV-506 Drug Info Discontinued in Phase 2 Angina pectoris [546047]
KCO-912 Drug Info Discontinued in Phase 2 Chronic obstructive pulmonary disease [547581]
KW-7158 Drug Info Discontinued in Phase 2 Urinary incontinence [547139]
P-1075 Drug Info Discontinued in Phase 2 Hypertension [544865]
Risotilide Drug Info Discontinued in Phase 2 Heart arrhythmia [545179]
Y-27152 Drug Info Discontinued in Phase 2 Angina pectoris [544925]
ZD-0947 Drug Info Discontinued in Phase 2 Overactive bladder disorder [546657]
ZD-6169 Drug Info Discontinued in Phase 2 Urinary incontinence [546120]
Emakalim Drug Info Discontinued in Phase 1 Angina pectoris [544976]
KR-30450 Drug Info Discontinued in Phase 1 Hypertension [545884]
NTC-801 Drug Info Discontinued in Phase 1 Atrial fibrillation; Atrial flutter [548263]
Rilmakalim Drug Info Discontinued in Phase 1 Chronic obstructive pulmonary disease [544828]
Ro-31-6930 Drug Info Discontinued in Phase 1 Hypertension [544524]
SDZ-PCO-400 Drug Info Discontinued in Phase 1 Asthma [544952]
SR-47063 Drug Info Discontinued in Phase 1 Cardiac arrhythmias [545164]
Symakalim Drug Info Discontinued in Phase 1 Hypertension [545492]
AL-0671 Drug Info Terminated Arteriosclerosis [545871]
Antiarrhythmics Drug Info Terminated Heart arrhythmia [547259]
AWD-23-111 Drug Info Terminated Heart arrhythmia [545974]
E-4080 Drug Info Terminated Angina pectoris [544975]
ICI-181037 Drug Info Terminated Heart arrhythmia [544804]
KC-399 Drug Info Terminated Alopecia [545323]
Ki-1769 Drug Info Terminated Hypertension [545263]
NS-004 Drug Info Terminated Hypertension [467608], [534399]
NS-1546 Drug Info Terminated Major depressive disorder [546073]
NS-1608 Drug Info Terminated Cerebrovascular ischaemia [546099]
Org-20781 Drug Info Terminated Heart arrhythmia [545460]
RP-66784 Drug Info Terminated Angina pectoris [545485]
S-1389 Drug Info Terminated Heart arrhythmia [544580]
SB-237376 Drug Info Terminated Arrhythmia [526551]
TCV-295 Drug Info Terminated Hypertension [545250]
TERIKALANT Drug Info Terminated Cardiac arrhythmias [544992]
UR-8225 Drug Info Terminated Asthma [545251]
UR-8308 Drug Info Terminated Asthma [545904]
UR-8328 Drug Info Terminated Asthma [545902]
WAY-123223 Drug Info Terminated Heart arrhythmia [544991]
YM-099 Drug Info Terminated Hypertension [545252]
Opener Acecainide Drug Info [528400]
AL-0671 Drug Info [533844]
Andolast Drug Info [529468]
AWD-23-111 Drug Info [534834]
BRL-55834 Drug Info [534028]
E-4080 Drug Info [528942]
Emakalim Drug Info [533839]
ICI-181037 Drug Info [529231]
Iptakalim hydrochloride Drug Info [531635], [531817]
JTV-506 Drug Info [525479]
KC-399 Drug Info [533609]
Ki-1769 Drug Info [533948]
KR-30450 Drug Info [531635], [534585]
MSH-1001 Drug Info [530084]
NS-004 Drug Info [534399]
NS-1546 Drug Info [546074]
NS-1608 Drug Info [534284]
Org-20781 Drug Info [545461]
P-1075 Drug Info [531373]
Rilmakalim Drug Info [527119]
Risotilide Drug Info [528009]
Ro-31-6930 Drug Info [532406]
RP-49356 Drug Info [531486]
RP-66784 Drug Info [534059]
S-1389 Drug Info [544581]
SDZ-PCO-400 Drug Info [526806]
SR-47063 Drug Info [525839]
TCV-295 Drug Info [531635], [533790]
UR-8225 Drug Info [533977]
UR-8308 Drug Info [545905]
UR-8328 Drug Info [545903]
WAY-123223 Drug Info [530230]
Y-27152 Drug Info [534178]
YM-099 Drug Info [533769]
ZD-0947 Drug Info [526383]
ZD-6169 Drug Info [526383]
Blocker Alinidine Drug Info [533559]
Ambasilide Drug Info [525482]
HBI-3000 Drug Info [531239]
Nibentan Drug Info [527507], [531635]
Trecetilide fumarate Drug Info [527182], [531635]
UK-66914 Drug Info [528531]
YM-934 Drug Info [533616]
Modulator Almokalant Drug Info
Amiodarone Drug Info [556264]
AVE0118 Drug Info
AZD-7009 Drug Info [532667]
Azimilide Drug Info
BMS-204352 Drug Info [1572591]
BRL-32872A Drug Info
CGS-7181 Drug Info
Dalfampridine Drug Info [531351]
Diazoxide Drug Info [556264]
Dofetilide Drug Info [556264]
E-4031 Drug Info
HMR1883 Drug Info
Ibutilide Drug Info [556264]
JTV 519 Drug Info
L 691121 Drug Info
Levcromakalim Drug Info
Minoxidil Drug Info [556264]
MJ-451 Drug Info
Nateglinide Drug Info [556264]
Pinacidil Drug Info [556264]
RP-66471 Drug Info
SB-237376 Drug Info [526551]
TERIKALANT Drug Info
WAY-125971 Drug Info [530230]
Y-26763 Drug Info
Inhibitor Antiarrhythmics Drug Info [547258]
NTC-801 Drug Info [532768]
Agonist Bimakalim Drug Info [527063]
BMS-180448 Drug Info [534264]
KCO-912 Drug Info [526289]
KW-7158 Drug Info [526989]
NS-8 Drug Info [532744]
Symakalim Drug Info [534618]
Binder CLP-1004 Drug Info [549414]
References
Ref 467589(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4254).
Ref 467608(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4271).
Ref 521760ClinicalTrials.gov (NCT00255281) Efficacy and Safety of AZD7009 in the Treatment of Atrial Fibrillation. U.S. National Institutes of Health.
Ref 523241ClinicalTrials.gov (NCT01235156) Efficacy and Safety of Sulcardine Sulfate Tablets in Patients With Premature Ventricular Contractions. U.S. National Institutes of Health.
Ref 526551Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41(3):414-21.
Ref 527063Lack of anti-ischemic efficacy of the potassium channel opener bimakalim in patients with stable angina pectoris. Cardiovasc Drugs Ther. 2004 Jan;18(1):37-46.
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 531817Iptakalim: A novel multi-utility potassium channel opener. J Pharmacol Pharmacother. 2012 Jan;3(1):12-4.
Ref 534342Electrophysiologic effects of nibentan (HE-11) on canine cardiac tissue. J Pharmacol Exp Ther. 1997 Mar;280(3):1137-46.
Ref 534399Effects of K+ channel inhibitors and antagonists on NS-004 evoked relaxations in guinea-pig isolated trachea. Fundam Clin Pharmacol. 1997;11(1):78-82.
Ref 536095New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 538235FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071344.
Ref 538482FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016996.
Ref 538525FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019456.
Ref 539459(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2307).
Ref 539538(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2409).
Ref 539542(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2412).
Ref 539657(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2566).
Ref 539666(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2588).
Ref 539681(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2604).
Ref 539682(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2605).
Ref 541914(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6833).
Ref 542214(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7200).
Ref 544517Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000036)
Ref 544524Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000054)
Ref 544558Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000131)
Ref 544580Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000214)
Ref 544588Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000232)
Ref 544609Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000286)
Ref 544619Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000315)
Ref 544642Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000403)
Ref 544654Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000439)
Ref 544804Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001161)
Ref 544820Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001219)
Ref 544828Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001252)
Ref 544865Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001364)
Ref 544925Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001561)
Ref 544932Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001581)
Ref 544952Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001697)
Ref 544960Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001721)
Ref 544975Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001760)
Ref 544976Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001761)
Ref 544977Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001764)
Ref 544991Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001818)
Ref 544992Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001820)
Ref 545161Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002324)
Ref 545164Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002328)
Ref 545179Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002381)
Ref 545250Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002578)
Ref 545251Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002580)
Ref 545252Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002582)
Ref 545263Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002625)
Ref 545323Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002834)
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Ref 545492Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003464)
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Ref 545902Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005293)
Ref 545904Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005294)
Ref 545974Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005585)
Ref 546047Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006044)
Ref 546073Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006187)
Ref 546099Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006351)
Ref 546120Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006442)
Ref 546657Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009535)
Ref 546835Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010536)
Ref 547139Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013319)
Ref 547259Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014534)
Ref 547581Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017535)
Ref 547751Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019047)
Ref 548251Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023795)
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Ref 549413Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036783)
Ref 551445Clinical pipeline report, company report or official report of Nippon Shinyaku Co Ltd.
Ref
Ref 525479Effects of the new potassium channel opener JTV-506 on coronary vessels in vitro and in vivo. Arzneimittelforschung. 1999 Mar;49(3):199-206.
Ref 525482Ambasilide prolongs the action potential and blocks multiple potassium currents in human atrium. J Cardiovasc Pharmacol. 1999 May;33(5):762-71.
Ref 525839Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta. Braz J Med Biol Res. 2000 Aug;33(8):961-6.
Ref 526289KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects. Naunyn Schmiedebergs Arch Pharmacol. 2002 Mar;365(3):220-30. Epub 2002 Jan 23.
Ref 526383Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats. J Urol. 2002 Aug;168(2):837-42.
Ref 526551Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41(3):414-21.
Ref 526806Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways. Br J Pharmacol. 1992 Jun;106(2):423-9.
Ref 526989KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat. J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. Epub 2004 Mar 9.
Ref 527063Lack of anti-ischemic efficacy of the potassium channel opener bimakalim in patients with stable angina pectoris. Cardiovasc Drugs Ther. 2004 Jan;18(1):37-46.
Ref 527119Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes. J Pharmacol Sci. 2004 Jun;95(2):189-95.
Ref 527182IKr channel blockers: novel antiarrhythmic agents. Curr Med Chem Cardiovasc Hematol Agents. 2003 Oct;1(3):203-23.
Ref 527507Nibentan -- a drug for pharmacological cardioversion of persistent atrial fibrillation. Kardiologiia. 2005;45(3):19-23.
Ref 528009Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade. Circulation. 1991 Jun;83(6):2067-75.
Ref 528400Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiac arrhythmias. Drugs. 1990 May;39(5):720-40.
Ref 528531Electrophysiologic properties of UK-66,914, a novel class III antiarrhythmic agent. J Cardiovasc Pharmacol. 1991 Mar;17(3):376-85.
Ref 528942Ionic currents involved in vasodilating actions of E4080, a newly synthesized bradycardia-inducing agent, in dispersed smooth muscle cells of the rabbit portal vein. J Pharmacol Exp Ther. 1991 Dec;259(3):1396-403.
Ref 529231ICI 181,037: a novel eukalemic diuretic with antiarrhythmic activity. Jpn J Pharmacol. 1991 Nov;57(3):263-77.
Ref 529468BK channel modulators: a comprehensive overview. Curr Med Chem. 2008;15(11):1126-46.
Ref 530084KR-31378, a potassium-channel opener, induces the protection of retinal ganglion cells in rat retinal ischemic models. J Pharmacol Sci. 2009 Apr;109(4):511-7.
Ref 530230Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives. J Med Chem. 1991 Nov;34(11):3212-28.
Ref 531239Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85.
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 531373The effects of potassium channel opener P1075 on the human saphenous vein and human internal mammary artery. J Cardiovasc Pharmacol. 2011 Jun;57(6):648-55.
Ref 531486Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells. Br J Pharmacol. 1990 Mar;99(3):487-92.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 531817Iptakalim: A novel multi-utility potassium channel opener. J Pharmacol Pharmacother. 2012 Jan;3(1):12-4.
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