Drug General Information
Drug ID
D0Y0ZB
Former ID
DIB007442
Drug Name
SB-219825
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Terminated [546476]
Company
SmithKline Beecham Corp
Structure
Download
2D MOL

3D MOL

Canonical SMILES
c1([nH]c2c(c1C)C[C@@H]1[C@](C2)(c2cc(O)ccc2)CCN(C1)CC)C<br />(=O)N(CC)CC
CAS Number
CAS 194798-70-4
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Modulator [526061]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546476Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008418)
Ref 526061Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sci. 2001 Apr 6;68(19-20):2233-42.

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