Drug Information

Drug General Information
Drug ID
D03OLA
Former ID
DNC004001
Drug Name
L-745631
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [546335]
Structure
Download
2D MOL

3D MOL
Formula
C21H29N3O2S
Canonical SMILES
COCCC1CN(CCN1CC(CS)N)C(=O)C2=CC=CC3=CC=CC=C32
InChI
1S/C21H29N3O2S/c1-26-12-9-18-14-24(11-10-23(18)13-17(22)15-27)21(25)20-8-4-6-16-5-2-3-7-19(16)20/h2-8,17-18,27H,9-15,22H2,1H3/t17-,18+/m0/s1
InChIKey
GKTZPBPAMFCBNI-ZWKOTPCHSA-N
PubChem Compound ID
44332320
Target and Pathway
Target(s) Geranylgeranyl transferase type I beta subunit Target Info Inhibitor [534466]
Protein farnesyltransferase beta subunit Target Info Inhibitor [534466]
Farnesyltransferase Target Info Inhibitor [534466]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-111465:Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransductionWP2776:Visual phototransduction
Apoptotic execution phase
References
Ref 546335Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007537)
Ref 534466J Med Chem. 1997 Sep 12;40(19):2971-90.Ras farnesyltransferase: a new therapeutic target.

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