Target Information
Target General Infomation | |||||
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Target ID |
T36056
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Former ID |
TTDR01070
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Target Name |
Geranylgeranyl transferase type I beta subunit
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Gene Name |
PGGT1B
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Synonyms |
GGTase-I-beta; Type I protein geranyl-geranyltransferase beta subunit; PGGT1B
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Target Type |
Discontinued
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
Function |
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the c-terminus of proteins having the c-terminal sequence cys-aliphatic-aliphatic-x. Acts on the rac1, rac2, rap1a and rap1b.
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BioChemical Class |
Alkyl aryl transferase
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Target Validation |
T36056
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UniProt ID | |||||
EC Number |
EC 2.5.1.59
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Sequence |
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS WKTKDSKQCSENVHIST |
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Drugs and Mode of Action | |||||
References | |||||
Ref 527321 | Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. |
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