Drug General Information |
Drug ID |
D00RMC
|
Former ID |
DIB001789
|
Drug Name |
BIBX-1382
|
Drug Type |
Small molecular drug
|
Indication |
Chronic lymphocytic leukaemia [ICD10:C91]
|
Phase 1 |
[1],
[2]
|
Company |
Boehringer Ingelheim Corp
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C18H19ClFN7
|
InChI |
InChI=1S/C18H19ClFN7/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24)
|
InChIKey |
FTFRZXFNZVCRSK-UHFFFAOYSA-N
|
CAS Number |
CAS 196612-93-8
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PubChem Compound ID |
|
PubChem Substance ID |
12015400, 14927526, 17194930, 26755049, 43529878, 57371960, 75419539, 85787657, 103567541, 114788081, 124892343, 135253520, 152258173, 160647010, 160854729, 163772750, 179322905, 185990427, 198975662, 203091614, 223365981, 223791700, 226522236, 244203145, 249963185, 251971394, 252451028
|
Target and Pathway |
Target(s) |
Epidermal growth factor receptor |
Target Info |
Antagonist |
[3]
|
KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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HIF-1 signaling pathway
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FoxO signaling pathway
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Endocytosis
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PI3K-Akt signaling pathway
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Dorso-ventral axis formation
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Focal adhesion
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Adherens junction
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Gap junction
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Oxytocin signaling pathway
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Epithelial cell signaling in Helicobacter pylori infection
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Hepatitis C
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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Pancreatic cancer
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Endometrial cancer
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Glioma
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Prostate cancer
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Melanoma
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Bladder cancer
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Non-small cell lung cancer
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Central carbon metabolism in cancer
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Choline metabolism in cancer
|
NetPath Pathway
|
IL4 Signaling Pathway
|
EGFR1 Signaling Pathway
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PANTHER Pathway
|
Cadherin signaling pathway
|
EGF receptor signaling pathway
|
Pathway Interaction Database
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LPA receptor mediated events
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Signaling events mediated by PTP1B
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Arf6 signaling events
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Signaling events mediated by TCPTP
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Thromboxane A2 receptor signaling
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SHP2 signaling
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Regulation of Telomerase
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EGF receptor (ErbB1) signaling pathway
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EGFR-dependent Endothelin signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
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Direct p53 effectors
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ErbB1 downstream signaling
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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E-cadherin signaling in keratinocytes
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ErbB receptor signaling network
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Internalization of ErbB1
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Stabilization and expansion of the E-cadherin adherens junction
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a6b1 and a6b4 Integrin signaling
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Syndecan-3-mediated signaling events
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Reactome
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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
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SHC1 events in ERBB2 signaling
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PLCG1 events in ERBB2 signaling
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PIP3 activates AKT signaling
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GRB2 events in EGFR signaling
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GAB1 signalosome
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SHC1 events in EGFR signaling
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EGFR downregulation
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GRB2 events in ERBB2 signaling
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PI3K events in ERBB2 signaling
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EGFR Transactivation by Gastrin
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Constitutive Signaling by Aberrant PI3K in Cancer
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Constitutive Signaling by EGFRvIII
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RAF/MAP kinase cascade
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WikiPathways
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ErbB Signaling Pathway
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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MAPK Signaling Pathway
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Focal Adhesion
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Aryl Hydrocarbon Receptor Pathway
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Extracellular vesicle-mediated signaling in recipient cells
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TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
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Bladder Cancer
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Hair Follicle Development: Induction (Part 1 of 3)
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Signaling by ERBB4
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Signaling by ERBB2
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Gastrin-CREB signalling pathway via PKC and MAPK
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PIP3 activates AKT signaling
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Nanoparticle-mediated activation of receptor signaling
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Aryl Hydrocarbon Receptor
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Gastric cancer network 2
|
AGE/RAGE pathway
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Signaling Pathways in Glioblastoma
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Arylhydrocarbon receptor (AhR) signaling pathway
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in epithelium - TarBase
|
Integrated Breast Cancer Pathway
|
Signaling by EGFR
|
L1CAM interactions
|
References |
REF 1 | ClinicalTrials.gov (NCT00003980) BIBX 1382 in Treating Patients With Solid Tumors. U.S. National Institutes of Health. |
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REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7646). |
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REF 3 | Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur J Cancer. 2002 May;38(8):1072-80. |