Drug Information

Drug General Information
Drug ID
D0S4BR
Former ID
DAP000763
Drug Name
Methimazole
Synonyms
Basolan; Danantizol; Favistan; Frentirox; MMZ; Mercaptazole; Mercasolyl; Mercazol; Mercazole; Mercazolyl; Mercazolylum; Merkastan; Merkazolil; Metazolo; Methamazole; Methiamazole; Methimazol; Methimazolum; Methizol; Methylmercaptoimidazole; Methymazol; Metimazol; Metisol; Metizol; Metothyrin; Metothyrine; Metotirin; Strumazol; Strumazole; Tapazole; Tapuzole; Thacapzol; Thiamazol; Thiamazole; Thiamazolum; Thimazol; Thimazole; Thycapsol; Thycapzol; Thymidazol; Thymidazole; Thyrozol; Tiamazol; Tiamazolo; Tirodril; EliLilly Brand of Methimazole; Estedi Brand of Methimazole; Henning Berlin Brand of Methimazole; Hexal Brand of Methimazole; Jones Brand of Methimazole; Merck Brand of Methimazole; Nourypharma Brand of Methimazole; Philopharm Brand of Methimazole; Sanofi Synthelabo Brand of Methimazole; Temmler Brand of Methimazole; Thiamazol Henning; Thiamazol Hexal; Tiamazolo [DCIT]; M0868; Henning, Thiamazol; Hexal, Thiamazol; Methimazole (USP); Methimazole [USAN:BAN]; Tapazole (TN); Thiamazol [INN-French]; Thiamazolum [INN-Latin]; Tiamazol [INN-Spanish]; Usaf el-30; Mestinon, Regonol, Pyridostigmine Bromide;Thiamazole (JP15/INN); N-Methyl-2-mercaptoimidazole; 1 Methyl 2 mercaptoimidazole; 1,3-Dihydro-1-Methyl-2H-Imidazol-2-Thione; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione; 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE; 1-Methyl-1,3-dihydroimidazole-2-thione; 1-Methyl-1H-imidazole-2-thiol; 1-Methyl-2-Imidazolethione; 1-Methyl-2-imidazolethiol; 1-Methyl-2-mercaptoimidazole; 1-Methyl-imidazole-2-thiol; 1-Methylimidazole-2(3H)-thione; 1-Methylimidazole-2-thiol; 1-Metylo 2 merkaptoimidazolem; 1-Metylo 2 merkaptoimidazolem [Polish]; 2-Mercapto-1-methylimidazole; 2-Mercaptomethylimidazole; 3-methyl-1H-imidazole-2-thione
Drug Type
Small molecular drug
Indication Hyperthyroidism [ICD9: 242; ICD10:E05] Approved [538176], [541759]
Therapeutic Class
Antithyroid Agents
Structure
Download
2D MOL

3D MOL
Formula
C4H6N2S
InChI
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey
PMRYVIKBURPHAH-UHFFFAOYSA-N
CAS Number
CAS 60-56-0
PubChem Compound ID
1349907
PubChem Substance ID
9399, 94517, 1668819, 3133765, 3347551, 3718115, 5065194, 5645940, 7847467, 7979929, 8139973, 8149418, 8830281, 10321919, 10529311, 11112158, 11335363, 11360602, 11363889, 11366451, 11369013, 11371589, 11373654, 11377175, 11461574, 11466814, 11467934, 11485002, 11486567, 11489089, 11490311, 11491863, 11494809, 11534268, 15194357, 15297082, 24858194, 24870159, 24882870, 24897266, 25623340, 26611812, 26679219, 26748131, 26748132, 29832410, 38350462, 46506536, 47365373, 47440128
ChEBI ID
ChEBI:50673
SuperDrug ATC ID
H03BB02
SuperDrug CAS ID
cas=000060560
Target and Pathway
Target(s) Thyroid peroxidase Target Info Inhibitor [537899]
BioCyc Pathway Thyroid hormone biosynthesis
KEGG Pathway Tyrosine metabolism
Metabolic pathways
Thyroid hormone synthesis
Autoimmune thyroid disease
NetPath Pathway TSH Signaling Pathway
PathWhiz Pathway Thyroid hormone synthesis
Reactome Thyroxine biosynthesis
WikiPathways Hematopoietic Stem Cell Differentiation
Differentiation Pathway
Metabolism of amino acids and derivatives
Thyroxine (Thyroid Hormone) Production
References
Ref 538176FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040350.
Ref 541759(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6649).
Ref 537899Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study. Eur J Endocrinol. 1994 Nov;131(5):467-73.

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