Target Information

Target General Infomation
Target ID
T51120
Former ID
TTDS00380
Target Name
Thyroid peroxidase
Gene Name
TPO
Synonyms
Thyroperoxidase; TPO
Target Type
Successful
Disease Hyperthyroidism [ICD9: 242; ICD10: E05]
Hyperthyroidism; Alcoholic hepatitis [ICD9:242, 571.1; ICD10: E05, K70.1]
Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10: D69.6, P61.0]
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
BioChemical Class
Peroxidases
Target Validation
T51120
UniProt ID
P07202
EC Number
EC 1.11.1.8
Sequence
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
Drugs and Mode of Action
Drug(s) Carbimazole Drug Info Approved Hyperthyroidism [550736]
Methimazole Drug Info Approved Hyperthyroidism [538176], [541759]
Propylthiouracil Drug Info Approved Hyperthyroidism; Alcoholic hepatitis [538392], [541761], [551871]
Inhibitor Carbimazole Drug Info [537899]
Methimazole Drug Info [537899]
Propyl thiouracile Drug Info [537831]
Propylthiouracil Drug Info [536420]
Thiamazole Drug Info [537899]
Modulator TPO gene plasmid Drug Info [543642]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Thyroid hormone biosynthesis
KEGG Pathway Tyrosine metabolism
Metabolic pathways
Thyroid hormone synthesis
Autoimmune thyroid disease
NetPath Pathway TSH Signaling Pathway
PathWhiz Pathway Thyroid hormone synthesis
Reactome Thyroxine biosynthesis
WikiPathways Hematopoietic Stem Cell Differentiation
Differentiation Pathway
Metabolism of amino acids and derivatives
Thyroxine (Thyroid Hormone) Production
References
Ref 538176FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040350.
Ref 538392FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 006188.
Ref 541759(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6649).
Ref 541761(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6650).
Ref 550736Drug information of Carbimazole, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536420Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl. 2006:23214. Epub 2006 Nov 12.
Ref 537831Theoretical aspects of the treatment with antithyroid drugs. Ann Endocrinol (Paris). 1994;55(1):1-5.
Ref 537899Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study. Eur J Endocrinol. 1994 Nov;131(5):467-73.
Ref 543642(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2526).

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