Drug General Information
Drug ID
D0Y2MV
Former ID
DAP000811
Drug Name
Orciprenaline
Synonyms
Alotec; Alupent; Astmopent; Metaprel; Metaproterenol; Novasmasol; Orciprenalina; Orciprenalinum; Prometa; Metaproterenol polistirex; Metaproterenol sulfate; Orciprenaline [INN]; Orciprenaline sulfate; Alotec (TN); Alupent (TN); M-3070; Metaprel (TN); Metaproterenol Polistirex (metaproterenol); Novasmasol (TN); Orciprenalina [INN-Spanish]; Orciprenaline (INN); Orciprenalinum [INN-Latin]; (RS)-1-(3,5-Dihydroxyphenyl)-2-isopropylaminoethanol; 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-(9CI); 3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol; 5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [542268], [550662]
Therapeutic Class
Bronchodilator Agents
Formula
C11H17NO3
InChI
InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3
InChIKey
LMOINURANNBYCM-UHFFFAOYSA-N
CAS Number
CAS 586-06-1
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
R03AB03; R03CB03
SuperDrug CAS ID
cas=000586061
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [536544]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 542268(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7250).
Ref 550662Drug information of Orciprenaline, 2008. eduDrugs.
Ref 536544Male--female differences in the impact of beta-adrenoceptor stimulation on resistance to experimental metastasis: exploring the effects of age and gonadal hormone involvement. J Neuroimmunol. 2008 Jan;193(1-2):113-9. Epub 2007 Nov 26.

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