Drug Information

Drug General Information
Drug ID
D0W2NM
Former ID
DAP000931
Drug Name
Flunitrazepam
Synonyms
Flunibeta; Flunimerck; Fluninoc; Flunitrazepamum; Fluridrazepam; Narcozep; Primun; Rohipnol; Rohypnol; Roipnol; Betapharm Brand of Flunitrazepam; Ct Arzneimittel Brand of Flunitrazepam; Flunitrazepam Teva; Flunitrazepam neuraxpharm; Flunitrazepam ratiopharm; Flunizep von ct; Hexal Brand of Flunitrazepam; Merck dura Brand ofFlunitrazepam; Neuraxpharm Brand of Flunitrazepam; Ratiopharm Brand of Flunitrazepam; Roche Brand of Flunitrazepam; Teva Brand of Flunitrazepam; Fluni 1A Pharma; RO54200; [3H]flunitrazepam; Ct-Arzneimittel Brand of Flunitrazepam; Darkene (TN); Flunipam (TN); Flunitrazepam-Teva; Flunitrazepam-neuraxpharm; Flunitrazepam-ratiopharm; Flunitrazepamum [INN-Latin]; Hipnosedon (TN); Hypnodorm (TN); Ilman(TN); Insom (TN); Nilium (TN); Ro 5-4200; Rohypnol (TN); Rufinol (TN); Silece (TN); Vulbegal (TN); RO-5-4200; Flunitrazepam (JP15/USAN/INN); Flunitrazepam [USAN:INN:BAN:JAN]; 1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; 1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one; 1A Brand of Flunitrazepam; 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one; 5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [467696], [550754]
Therapeutic Class
Hypnotics and Sedatives
Company
Roche Laboratories Inc
Structure
Download
2D MOL

3D MOL
Formula
C16H12FN3O3
InChI
InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
InChIKey
PPTYJKAXVCCBDU-UHFFFAOYSA-N
CAS Number
CAS 1622-62-4
PubChem Compound ID
3380
PubChem Substance ID
529943, 5367816, 6018772, 7848293, 7849646, 8150136, 8152151, 10509780, 11336156, 11361395, 11462367, 15494069, 24894993, 29222515, 46504553, 47291209, 48416024, 49884241, 53786877, 56413166, 57321765, 71821460, 79315430, 99302069, 103174540, 104303344, 109613212, 126691439, 128950759, 128950760, 131300954, 134338207, 134961908, 134979679, 136949637, 137002941, 141004720, 143054817, 160839433, 160964789, 162956355, 163402580, 164788746, 178101010, 178101176, 179148568, 184547588, 196104471, 198960206, 198991798
SuperDrug ATC ID
N05CD03
SuperDrug CAS ID
cas=001622624
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Agonist [537330]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 467696(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4360).
Ref 550754Drug information of Flunitrazepam, 2008. eduDrugs.
Ref 537330Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46.

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