Drug General Information
Drug ID
D03DIG
Former ID
DAP000213
Drug Name
Codeine
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538268], [539036]
Cough [ICD9: 786.2; ICD10:R05] Phase 1 [533409], [539036]
Therapeutic Class
Analgesics
Company
Forest Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C18H21NO3
InChIKey
OROGSEYTTFOCAN-DNJOTXNNSA-N
CAS Number
CAS 76-57-3
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:16714
SuperDrug ATC ID
R05DA04
SuperDrug CAS ID
cas=000076573
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [536098]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 533409Effects of a mu-opioid receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man. Br J Clin Pharmacol. 1986 Nov;22(5):507-12.
Ref 538268FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074256.
Ref 539036(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1673).
Ref 536098Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16. Epub 2005 Jun 8.

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