Drug General Information
Drug ID	D0C2FM
Former ID	DIB018344
Drug Name	[3H]M-MPEP
Synonyms	[3H]-M-MPEP
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538903]
Structure		Download 2D MOL 3D MOL
Formula	C15H13NO
InChI	InChI=1S/C15H13NO/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-2/h3-8,11H,1-2H3
InChIKey	STDHINPODVHROK-UHFFFAOYSA-N
PubChem Compound ID	5311462
PubChem Substance ID	7980686, 11056525, 15464125, 39341135, 47359843, 48029598, 50733008, 57359493, 58670161, 103344919, 104015609, 114156163, 129285056, 134344552, 135651179, 179294105, 227272767
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Modulator (allosteric modulator)	[526258]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538903	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1425).
Ref 526258	[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. Bioorg Med Chem Lett. 2002 Feb 11;12(3):407-9.

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