Drug General Information
Drug ID	D0RJ5B
Former ID	DNC006454
Drug Name	4-(3-bromophenylthio)-2-(pyridin-2-yl)pyrimidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528038]
Structure		Download 2D MOL 3D MOL
Formula	C15H10BrN3S
Canonical SMILES	C1=CC=NC(=C1)C2=NC=CC(=N2)SC3=CC(=CC=C3)Br
InChI	1S/C15H10BrN3S/c16-11-4-3-5-12(10-11)20-14-7-9-18-15(19-14)13-6-1-2-8-17-13/h1-10H
InChIKey	GOUWEKQNTSGAGA-UHFFFAOYSA-N
PubChem Compound ID	11473392
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[528038]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528038	Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
Ref 528038	Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.

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