Drug General Information
Drug ID	D08NOP
Former ID	DNC013391
Drug Name	2-methyl-7-m-tolyl-1,6-naphthyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529101]
Structure		Download 2D MOL 3D MOL
Formula	C16H14N2
Canonical SMILES	CC1=NC2=CC(=NC=C2C=C1)C3=CC(=CC=C3)C
InChI	1S/C16H14N2/c1-11-4-3-5-13(8-11)15-9-16-14(10-17-15)7-6-12(2)18-16/h3-10H,1-2H3
InChIKey	RXRAEDHCPCFPLI-UHFFFAOYSA-N
PubChem Compound ID	44434750
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[529101]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529101	Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
Ref 529101	Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.

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