Drug General Information
Drug ID	D09CXX
Former ID	DNC010904
Drug Name	N-hydroxysulfamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530922]
Structure		Download 2D MOL 3D MOL
Formula	H4N2O3S
Canonical SMILES	NS(=O)(=O)NO
InChI	1S/H4N2O3S/c1-6(4,5)2-3/h2-3H,(H2,1,4,5)
InChIKey	FZTCJYJKHSXPEX-UHFFFAOYSA-N
PubChem Compound ID	16122590
Target and Pathway
Target(s)	Carbonic anhydrase IX	Target Info	Inhibitor	[530922]
	Carbonic anhydrase II	Target Info	Inhibitor	[530922]
	Carbonic anhydrase XII	Target Info	Inhibitor	[530922]
	Carbonic anhydrase I	Target Info	Inhibitor	[530922]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Vitamin D Receptor Pathway
	Reversible Hydration of Carbon Dioxide
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530922	Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
Ref 530922	Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.

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