Drug Information

Drug General Information
Drug ID
D08SYN
Former ID
DNC014419
Drug Name
3-cyano-N-(6-ethylpyridin-2-yl)-5-fluorobenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531010]
Structure
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2D MOL

3D MOL
Formula
C15H12FN3O
Canonical SMILES
CCC1=NC(=CC=C1)NC(=O)C2=CC(=CC(=C2)C#N)F
InChI
1S/C15H12FN3O/c1-2-13-4-3-5-14(18-13)19-15(20)11-6-10(9-17)7-12(16)8-11/h3-8H,2H2,1H3,(H,18,19,20)
InChIKey
LBPUNEZWEHBQQO-UHFFFAOYSA-N
PubChem Compound ID
49862385
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [531010]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531010Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.
Ref 531010Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.

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