Drug Information

Drug General Information
Drug ID
D0L6PL
Former ID
DNC007533
Drug Name
3-biphenyl-4-ylethynyl-5-methyl-[1,2,4]triazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528893]
Structure
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2D MOL

3D MOL
Formula
C18H13N3
Canonical SMILES
CC1=CN=NC(=N1)C#CC2=CC=C(C=C2)C3=CC=CC=C3
InChI
1S/C18H13N3/c1-14-13-19-21-18(20-14)12-9-15-7-10-17(11-8-15)16-5-3-2-4-6-16/h2-8,10-11,13H,1H3
InChIKey
OXVAGVMMJCNKRK-UHFFFAOYSA-N
PubChem Compound ID
16735659
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528893]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528893J Med Chem. 2007 Jul 12;50(14):3388-91. Epub 2007 Jun 15.Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Ref 528893J Med Chem. 2007 Jul 12;50(14):3388-91. Epub 2007 Jun 15.Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.

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