Drug General Information
Drug ID	D03BRB
Former ID	DNC013028
Drug Name	(H-Dmt-Tic-Glu-NH-(CH(2))(5)-CO-Dap(6DMN)-NH(2)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528238]
Structure		Download 2D MOL 3D MOL
Formula	C49H58N8O10
PubChem Compound ID	44412158
Target and Pathway
Target(s)	Delta-type opioid receptor	Target Info	Inhibitor	[528238]
	Mu-type opioid receptor	Target Info	Inhibitor	[528238]
KEGG Pathway	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
	Opioid proenkephalin pathway
	Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signalingWP69:TCR Signaling Pathway
	Opioid Signalling
	GPCR downstream signaling
References
Ref 528238	J Med Chem. 2006 Jun 15;49(12):3653-8.6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Ref 528238	J Med Chem. 2006 Jun 15;49(12):3653-8.6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

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