Drug Information

Drug General Information
Drug ID
D0K1BV
Former ID
DNC010085
Drug Name
N-(17-Methylmorphinan-3-yl)-N'-phenylurea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530529]
Structure
Download
2D MOL

3D MOL
Formula
C24H29N3O
Canonical SMILES
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)NC(=O)NC5=CC=CC=C5
InChI
1S/C24H29N3O/c1-27-14-13-24-12-6-5-9-20(24)22(27)15-17-10-11-19(16-21(17)24)26-23(28)25-18-7-3-2-4-8-18/h2-4,7-8,10-11,16,20,22H,5-6,9,12-15H2,1H3,(H2,25,26,28)/t20-,22+,24+/m0/s1
InChIKey
CVZRQQXQPKBKNJ-BGWNEDDSSA-N
PubChem Compound ID
44628003
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [530529]
Delta-type opioid receptor Target Info Inhibitor [530529]
Mu-type opioid receptor Target Info Inhibitor [530529]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signaling
References
Ref 530529J Med Chem. 2010 Jan 14;53(1):402-18.Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.
Ref 530529J Med Chem. 2010 Jan 14;53(1):402-18.Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.