Drug Information

Drug General Information
Drug ID
D0VN4K
Former ID
DNC001129
Drug Name
PK 11195
Drug Type
Small molecular drug
Indication Discovery agent Terminated [543258], [544695]
Structure
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2D MOL

3D MOL
Formula
C21H21ClN2O
InChI
InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
InChIKey
RAVIZVQZGXBOQO-UHFFFAOYSA-N
CAS Number
CAS 10465-78-8
PubChem Compound ID
1345
PubChem Substance ID
5195352, 8151100, 11532932, 12015392, 14900970, 17404761, 24278822, 24439687, 26751834, 47440477, 47662507, 47810972, 47810973, 48035345, 49845849, 49845856, 49986420, 50104534, 50104535, 53777304, 53789464, 56312856, 57320876, 77248398, 85084791, 85230956, 85788339, 90340882, 91703379, 92303464, 103656034, 103858286, 104297470, 121360961, 124749535, 124800739, 124879541, 124879542, 124879543, 124879544, 125563859, 129102761, 134340126, 134340367, 134348755, 135089849, 135697515, 137148685, 142527063, 144210937
ChEBI ID
ChEBI:48958
SuperDrug ATC ID
R03DX06
SuperDrug CAS ID
cas=112665437
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Binder [535317]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 543258(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8703).
Ref 544695Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000635)
Ref 535317Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80.

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