Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04SNH
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| Former ID |
DNC011193
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| Drug Name |
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [530978] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C12H12N2O3S
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| Canonical SMILES |
C1=CC=C(C=C1)CN2C=CC(=O)C(=C2)S(=O)(=O)N
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| InChI |
1S/C12H12N2O3S/c13-18(16,17)12-9-14(7-6-11(12)15)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H2,13,16,17)
|
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| InChIKey |
WIIFYOJVUKTZDG-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase XII | Target Info | Inhibitor | [530978] | |
| Carbonic anhydrase II | Target Info | Inhibitor | [530978] | ||
| Carbonic anhydrase I | Target Info | Inhibitor | [530978] | ||
| Carbonic anhydrase IX | Target Info | Inhibitor | [530978] | ||
| Pathway Interaction Database | C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in leukocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | |||||
| References | |||||
| Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
| Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
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