Drug Information

Drug General Information
Drug ID
D0B3BJ
Former ID
DNC006842
Drug Name
ICI-174864
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539010]
Structure
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2D MOL

3D MOL
Formula
C34H46N4O6
InChI
InChI=1S/C34H46N4O6/c1-7-18-38(19-8-2)29(22-25-14-16-26(39)17-15-25)31(41)37-34(5,6)33(44)36-27(21-24-12-10-9-11-13-24)30(40)35-28(32(42)43)20-23(3)4/h7-17,23,27-29,39H,1-2,18-22H2,3-6H3,(H,35,40)(H,36,44)(H,37,41)(H,42,43)/t27-,28-,29-/m0/s1
InChIKey
BGJPRBZZLWCLJW-AWCRTANDSA-N
PubChem Compound ID
107691
PubChem Substance ID
14789457, 24453785, 44436664, 47359925, 47510092, 50065362, 56335586, 57338186, 75541586, 103835910, 104028671, 104379498, 117541564, 134222930, 135064943, 135650369, 230334648
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Inhibitor [528410]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539010(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1636).
Ref 528410J Med Chem. 2006 Sep 7;49(18):5597-609.Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.

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