Drug General Information
Drug ID	D04ILS
Former ID	DNC006422
Drug Name	2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527989]
Structure		Download 2D MOL 3D MOL
Formula	C13H8Cl2N2O
Canonical SMILES	C1=CC(=CC(=C1)Cl)COC2=NC(=CC(=C2)C#N)Cl
InChI	1S/C13H8Cl2N2O/c14-11-3-1-2-9(4-11)8-18-13-6-10(7-16)5-12(15)17-13/h1-6H,8H2
InChIKey	MGYAMTJNJZZLMV-UHFFFAOYSA-N
PubChem Compound ID	44409846
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[527989]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527989	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
Ref 527989	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

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