Drug Information
Drug General Information | |||||
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Drug ID |
D0V9BD
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Former ID |
DAP000092
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Drug Name |
Bicalutamide
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Synonyms |
Casodex; Cosudex; Propanamide; Raffolutil; Astra brand of bicalutamide; AstraZeneca brand of bicalutamide; Zeneca brand of bicalutamide; Calutide (TN); Casodex (TN); Cosudex (TN); KS-1161; Kalumid (TN); Bicalutamide [USAN:INN:BAN]; Bicalutamide (JAN/USP/INN); Casodex, Cosudex, Calutide, Kalumid, Bicalutamide; N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide; (+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide; 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide
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Drug Type |
Small molecular drug
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Therapeutic Class |
Anticancer Agents
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Company |
AstraZeneca plc
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Structure |
Download2D MOL |
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Formula |
C18H14F4N2O4S
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InChI |
InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
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InChIKey |
LKJPYSCBVHEWIU-UHFFFAOYSA-N
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CAS Number |
CAS 90357-06-5
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PubChem Compound ID | |||||
PubChem Substance ID |
10360, 536636, 4422035, 7848024, 7978493, 8151593, 11528703, 12014029, 14807515, 26719836, 29221542, 46386630, 46505386, 46518598, 49681685, 49835627, 50113021, 50709017, 53790604, 57321290, 85174226, 85174230, 90341766, 91610973, 92308263, 92308948, 92711409, 93815120, 99016301, 99437214, 103164349, 104300407, 118046574, 121362017, 124658945, 124757067, 124800143, 124893438, 125163871, 125338410, 125359510, 125545351, 126630887, 126657361, 126665838, 128501765, 131295154, 134358448, 135014383, 135649993
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ChEBI ID |
ChEBI:3090
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SuperDrug ATC ID |
L02BB03
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SuperDrug CAS ID |
cas=090357065
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Drug Resistance Mutation (DRM) | |||||
DRM | DRM Info | ||||
Target and Pathway | |||||
Target(s) | Androgen receptor | Target Info | Antagonist | [535561], [537480] | |
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Coregulation of Androgen receptor activity | |||||
Regulation of Androgen receptor activity | |||||
Nongenotropic Androgen signaling | |||||
Regulation of nuclear beta catenin signaling and target gene transcription | |||||
FOXA1 transcription factor network | |||||
Notch-mediated HES/HEY network | |||||
References | |||||
Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
Ref 539888 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2863). |
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