Drug Information

Drug General Information
Drug ID
D08OBF
Former ID
DNC002439
Drug Name
MYRISTIC ACID
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539847]
Structure
Download
2D MOL

3D MOL
Formula
C14H28O2
InChI
InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)
InChIKey
TUNFSRHWOTWDNC-UHFFFAOYSA-N
PubChem Compound ID
11005
PubChem Substance ID
8659, 71201, 584425, 598231, 819798, 821625, 821629, 827243, 827463, 828862, 829963, 830804, 830816, 832936, 841695, 3135819, 5582017, 7849668, 7889105, 8026552, 8026620, 8026622, 8027944, 8027949, 8027955, 8027957, 8137854, 8144261, 8158012, 10526410, 14892448, 17389652, 17435987, 17435990, 24874906, 24886048, 24886049, 24896795, 24896947, 24901313, 24901314, 26703255, 26707044, 26708943, 26752895, 29204417, 29279354, 31561508, 48414858, 48417591
Target and Pathway
Target(s) Negative factor Target Info Inhibitor [551374]
Proto-oncogene c-Abl Target Info Inhibitor [551374]
UDP-3-O-[3-hydroxymyristoyl] n-acetylglucosamine deacetylase Target Info Inhibitor [551374]
Hepatocyte nuclear factor 4-alpha Target Info Inhibitor [551374]
Calmodulin Target Info Inhibitor [551374]
Toll-like receptor 4 Target Info Inhibitor [551374]
Recoverin Target Info Inhibitor [551374]
Genome polyprotein Target Info Inhibitor [551374]
Lymphocyte antigen 96 Target Info Inhibitor [551374]
FK506-binding protein 1A Target Info Inhibitor [551374]
KEGG Pathway ErbB signaling pathway
Ras signaling pathway
Cell cycle
Axon guidance
Neurotrophin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Pathways in cancer
MicroRNAs in cancer
Chronic myeloid leukemia
Viral myocarditispae00540:Lipopolysaccharide biosynthesis
Metabolic pathwayshsa04152:AMPK signaling pathway
Maturity onset diabetes of the younghsa04014:Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Long-term potentiation
Dopaminergic synapse
Olfactory transduction
Phototransduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Salivary secretion
Gastric acid secretion
Alzheimer's disease
Amphetamine addiction
Alcoholism
Pertussis
Tuberculosis
Gliomahsa04064:NF-kappa B signaling pathway
HIF-1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Salmonella infection
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Hepatitis B
Measles
Influenza A
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritishsa04744:Phototransductionhsa04064:NF-kappa B signaling pathway
NetPath Pathway RANKL Signaling Pathway
TSH Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
IL6 Signaling Pathway
PANTHER Pathway Axon guidance mediated by Slit/RoboP06959:CCKR signaling map STP00054:Toll receptor signaling pathwayP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00054:Toll receptor signaling pathway
Pathway Interaction Database p73 transcription factor network
ATM pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor networkbcr_5pathway:BCR signaling pathway
p38 MAPK signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2 signaling events mediated by PI3K
IFN-gamma pathway
ErbB1 downstream signaling
VEGFR1 specific signals
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Calcium signaling in the CD4+ TCR pathway
Signaling events mediated by VEGFR1 and VEGFR2
Insulin-mediated glucose transport
N-cadherin signaling events
Cellular roles of Anthrax toxin
Regulation of Ras family activation
Downstream signaling in na&#xef
Endogenous TLR signalingtoll_endogenous_pathway:Endogenous TLR signaling
PathWhiz Pathway Muscle/Heart Contraction
Reactome Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet productionR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-111933:Calmodulin induced events
Platelet degranulation
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
DARPP-32 events
eNOS activation
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
RHO GTPases activate IQGAPs
RAF/MAP kinase cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-140534:Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR3/TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complexR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-140534:Ligand-dependent caspase activation
TRAF6 mediated induction of TAK1 complex
WikiPathways Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet productionWP2857:Mesodermal Commitment Pathway
Nuclear Receptors
AMPK SignalingWP2777:Translocation of GLUT4 to the Plasma Membrane
Visual phototransduction
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by the B Cell Receptor (BCR)
Inositol phosphate metabolism
DAG and IP3 signaling
Opioid Signalling
Muscle contraction
Metabolism of nitric oxide
Metabolism of carbohydratesWP75:Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent cascade
Primary Focal Segmental Glomerulosclerosis FSGS
Spinal Cord Injury
Corticotropin-releasing hormone
Regulation of toll-like receptor signaling pathwayWP2776:Visual phototransductionWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
References
Ref 539847(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2806).
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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