Drug Information

Drug General Information
Drug ID
D0K5KL
Former ID
DNC000362
Drug Name
BW 373U86
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545029]
Structure
Download
2D MOL

3D MOL
Formula
C27H37N3O2
Canonical SMILES
CCN(CC)C(=O)C1=CC=C(C=C1)C(C2=CC(=CC=C2)O)N3CC(N(CC3C)C<br />C=C)C
InChI
1S/C27H37N3O2/c1-6-16-29-18-21(5)30(19-20(29)4)26(24-10-9-11-25(31)17-24)22-12-14-23(15-13-22)27(32)28(7-2)8-3/h6,9-15,17,20-21,26,31H,1,7-8,16,18-19H2,2-5H3/t20-,21+,26-/m1/s1
InChIKey
LBLDMHBSVIVJPM-YZIHRLCOSA-N
CAS Number
CAS 68-41-7
PubChem Compound ID
119029
PubChem Substance ID
10238308, 11114171, 15354409, 29300005, 50074266, 57339284, 77740044, 85788672, 103193996, 103946289, 104407369, 128465049, 134223401, 134339806, 134346144, 135075283, 135698559, 137272197, 142093556, 162023315, 224181333, 226584029, 241182610, 241375566, 249617369
ChEBI ID
ChEBI:40009
SuperDrug ATC ID
J04AB01
SuperDrug CAS ID
cas=000068417
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [535207]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 545029Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001926)
Ref 535207BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. J Mol Cell Cardiol. 2001 Aug;33(8):1455-65.

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