Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D0C7WG
|
||||
Former ID |
DNC010197
|
||||
Drug Name |
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Discovery agent | Investigative | [530399] | ||
Structure |
Download2D MOL |
||||
Formula |
C12H11N3O3S
|
||||
Canonical SMILES |
C1=CC(=CC(=C1)S(=O)(=O)N)NN=C2C=CC(=O)C=C2
|
||||
InChI |
1S/C12H11N3O3S/c13-19(17,18)12-3-1-2-10(8-12)15-14-9-4-6-11(16)7-5-9/h1-8,15H,(H2,13,17,18)
|
||||
InChIKey |
YLKIHWZCLCNOER-UHFFFAOYSA-N
|
||||
PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase IX | Target Info | Inhibitor | [530399] | |
Carbonic anhydrase II | Target Info | Inhibitor | [530292] | ||
Carbonic anhydrase XII | Target Info | Inhibitor | [530399] | ||
Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
Reactome | Regulation of gene expression by Hypoxia-inducible Factor | ||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide | |||||
WikiPathways | Vitamin D Receptor Pathway | ||||
Reversible Hydration of Carbon Dioxide | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
References | |||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 530399 | Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.